Year: 2025
Type: article
Abstract: In this issue of Blood, Wu et al 1 study the function of circular RNA (circRNA) in platelet production.Following a trail of evidence that began with the observation that megakaryocytes and platelets express high levels of one particular circRNA, circFUT8, the team discovered that circFUT8 interacts with insulin-like growth factor 2 messenger RNA (mRNA) binding protein 2 (IGF2BP2) to promote the stabilization of tensin 1 (TNS1) mRNA (see figure).This mechanism exemplifies 1 function of circRNA, which is to modulate mRNA stability.
Source: Blood
Authors: Amelia A. Rodolf, Owen J. T. McCarty
Institution: Oregon Health & Science University
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4415478423