Work

Photocatalytic Addition of N -Oxazolidinone Radicals to Arenes and Heteroarenes in Batch and in Flow Mode

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Recent progress in N -centered radical chemistry has paved the way for unprecedented transformations in organic synthesis, particularly through photocatalytic C–N bond formation reactions. Here, unexplored N -oxazolidinone radicals are generated through visible light irradiation, enabling a novel, efficient, sustainable, and scalable C–H functionalization process of arenes and heteroarenes. Crucially, the use of continuous flow processing was found to provide further advantages over standard batch conditions, which will enable further applications of this important transformation.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c03828

Authors: Sara Ferrario, Sergio Rossi, Niccolò Intini, Julia Bruno-Colmenarez, Marcus Baumann, Maurizio Benaglia

Institutions: University of Milan, University College Dublin

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Ministero dell’Istruzione, dell’Università e della Ricerca, NextGenerationEU, Research Ireland