Work

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

Year: 2025

Type: article

Abstract: Introduction: This study investigated the protective effects of baicalin on retinal ganglion cells (RGCs) subjected to ischemia-reperfusion injury and explored the underlying mechanisms. Methods: model of oxygen-glucose deprivation/reperfusion (OGD/R) in a microglia-RGC co-culture system, we examined the protective role of baicalin against RGC injury. Results: The results demonstrated that baicalin significantly suppressed the M1 polarization of microglia, promoted their shift toward M2 polarization, and alleviated oxidative stress and ferroptosis in RGCs by inhibiting the JAK2/STAT3 signaling pathway. Conclusion: This study reveals that baicalin protects RGCs by modulating microglial polarization and inhibiting ferroptosis, providing novel insights for the treatment of glaucoma.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1660294

Authors: Huan Yu, Tianzhao Xu, Qiaozong Feng, Yilin Wang, Jun Zou, Xiaoyun Ma

Institutions: Shanghai University of Medicine and Health Sciences, Tongji University, Shanghai Tenth People's Hospital

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801