Year: 2025
Type: article
Study design: Observational Study
Abstract: Antenatal corticosteroids (ACs) improve the outcomes of preterm neonates [1].However, in recent years, large populationbased studies have also associated AC treatment with later harms.These harms include, for example, an increased risk for infectious diseases, neurosensory disorders, mental disorders, and delayed psychological development [2].Most of these risks have not been confirmed in randomised trials, such as a recent 50-year follow-up study after exposure to AC or placebo [3].However, an increased risk of osteoporotic fractures was seen after exposure to AC in comparison to placebo [3].Since corticosteroids have a direct impact on bone mineralization as they impact both osteoclast and osteoblast functions, we aimed to investigate the risk of fractures close to the AC exposure in early childhood in a large population-based cohort.For this nationwide register-based cohort study, we included all neonates born alive in Finland between 2005 and 2017 from the Finnish Medical Birth Register.It includes information on
Authors: Ilari Kuitunen, Reijo Sund, Ulla Sankilampi
Institutions: University of Eastern Finland, Kuopio University Hospital
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W4415496747