The Effect of Clay‐ and Yeast‐Based Mycotoxin Binder on Performance, Lymphoid Organs, Blood Parameters, Immune Response and Haematology Parameters of Broilers Exposed to Aflatoxin B 1
Year: 2025
Type: article
Abstract: ABSTRACT Background Feeding broilers aflatoxin‐contaminated feed can disrupt the bird's performance, immune system and organs such as the liver, kidneys and heart. One possible strategy to minimise the inevitable impact of aflatoxins could be the use of toxic binders in the feed. Objectives The present study aimed to investigate the effect of mycotoxin binder magnotox (MAG) in reducing the toxicity of aflatoxin B 1 (AFB 1 ) on performance, lymphoid organs, blood parameters, immune response and haematology parameters of broiler chickens. Methods A total of 240 1‐day‐old male broiler chicks of Ross 308 strain with an average 1‐day weight of 43.47 ± 0.28 g were used. This experiment was conducted as a 2 × 2 factorial in a completely randomised design with four treatments and six replications. The experimental diets included two levels of AFB 1 (0 and 200 µg/kg) and two levels of MAG (0 and 1 g/kg). Results The interaction effects of AFB 1 and MAG showed that adding 1 g/kg MAG to the AFB 1 ‐containing diet improved BWG compared to the AFB 1 ‐containing diet without MAG at 1–24, 25–42 and 1–42 days of age. Exposure to 200 µg/kg AFB 1 increased the percentage of liver, kidney and pancreas, and the use of 1 g/kg MAG in the AFB 1 ‐containing diet significantly reduced the weight of these organs ( p < 0.05). Regarding liver enzymes, MAG compensated for the increase in ALP, AST and ALT concentrations caused by AFB 1 and reduced them similarly to the control treatment ( p < 0.01). AFB 1 exposure decreased IgG (24 and 42 days), IgM (24 days) and IgA (42 days) but the use of 1 g/kg MAG in AFB 1 ‐contaminated diets was able to compensate for the negative effects of AFB 1 and significantly increase the concentration of IgG, IgM and IgA. The interaction of MAG and AFB 1 showed that IBD and ND titres were reduced in AFB 1 ‐contaminated diets at 24 and 42 days of age but the use of MAG increased IBD and ND titres ( p = 0.001). Conclusions Overall, broilers fed diets contaminated with 200 µg/kg AFB 1 showed poor growth performance throughout the period due to impaired immune function and inflammation of immune organs, but supplementation with 1 g/kg MAG counteracted the negative effects caused by AFB 1 and improved growth performance.
Source: Veterinary Medicine and Science
DOI: 10.1002/vms3.70625
Authors: Payman Mahmoudi Nasr, Kaveh Jafari Khorshidi
Institution: Qaemshahr Islamic Azad University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,880
OpenAlex ID: W4415497548