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Multidisciplinary Intensive Care Management of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome: A Case Report

Year: 2025

Type: article

Abstract: We present the case of a 65-year-old man with long-standing polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome, who developed progressive multi-organ dysfunction requiring support in the intensive care unit (ICU). The patient's course was complicated by nodular regenerative hyperplasia (NRH) contributing to non-cirrhotic portal hypertension and severe ascites, acute kidney injury (AKI), hemodynamic instability, and endocrine abnormalities. Management involved multidisciplinary coordination across critical care, hematology, nephrology, and endocrinology teams, with prophylactic antimicrobial therapy, careful hemodynamic optimization, and individualized nutritional and endocrine support. This case highlights the complexity of ICU management in POEMS syndrome, demonstrating the importance of early recognition, collaborative care, and tailored interventions in optimizing outcomes for critically ill patients.

Source: Cureus

DOI: 10.7759/cureus.95290

Authors: Zaza Aladashvili, Thalia B Rodriguez, Elene Zaalishvili, Luka Beridze, Yaroslav Buryk

Institutions: Tbilisi State Medical University, Jackson Memorial Hospital, Ross University School of Medicine, David Tvildiani Medical University, Petre Shotadze Tbilisi Medical Academy

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415501619