Work

The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies

Year: 2025

Type: article

Abstract: Candidate PET ligands targeting pathological TDP-43 aggregates are characterized by Vokali and colleagues in a series of human tissue, cell/animal model, and non-human primate experiments. Their preclinical data suggests favorable specificity and pharmacokinetic profiles of their two candidate tracers, which could translate into a disease-specific biomarker in TDP-43 proteinopathies.

Source: Nature Communications

DOI: 10.1038/s41467-025-64541-5

Author: David J. Irwin

Institution: University of Pennsylvania

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990