Work

Design, synthesis, and biological evaluation of sulfonamide-functionalized pyridine carbothioamides as potent tubulin-targeting anticancer agents

Year: 2025

Type: article

Abstract: ADME predictions indicated that the most lipophilic compounds 3 and 5 demonstrated favorable drug-likeness, as expected from computational studies, along with excellent gastrointestinal absorption, favorable bioavailability, and low hemolytic activity. Collectively, these findings highlight compounds 3 and 5 as promising lead candidates for the development of orally active anticancer and antimitotic agents.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00693g

Authors: Fatima Younas, Jahan Zaib Arshad, Waqas Ali Shah, Sundas Arshad, Adnan Ashraf, Syed Shoaib Ahmad Shah, Muhammad Asam Raza, Amara Mumtaz, Nasir Shahzad, Tariq Javed

Institutions: Government College Women University Sialkot, Henan Normal University, Wuhan University of Science and Technology, University of Lahore, National University of Sciences and Technology, University of Gujrat, COMSATS University Islamabad, University of Sahiwal

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Higher Education Commision, Pakistan

Awards: G5032240058, G962897519

OpenAlex ID: W4415507805

FWCI: 0.894

Cites: 74

Cited by: 3

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