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Plasma concentrations of mirtazapine are significantly different between sampling sites after oral administration in alpacas

Year: 2025
Type: article
Abstract: Objective: To evaluate the pharmacokinetics of mirtazapine (MRZ) after single-dose oral administration in healthy adult alpacas and compare concentrations at 2 venous sampling sites. Methods: This study was conducted during the weeks of January 29, 2024, and February 15, 2024. A single dose of 2 mg/kg MRZ was administered orally via syringe to 7 healthy adult alpacas. Blood was collected from jugular vein (JV; n = 7) and cephalic vein (CV; 5) catheters immediately prior to and at predetermined times for 24 hours after administration. Plasma MRZ concentrations were determined by UPLC-MS-MS. Pharmacokinetic parameters were determined for each sampling site, and statistical analysis was performed by paired t tests. Results: Mean maximum plasma concentrations (Cmax) from JV samples (183 ± 95.2 ng/mL) occurred at time 0.0281 ± 0.029 hours and were significantly higher than CV samples' Cmax (4.84 ± 2.37 ng/mL), which occurred at time 0.464 ± 0.093 hours. Comparison of dose-corrected Cmax and area under the concentration-time curve from time zero extrapolated to infinity with those previously reported show the Cmax from JV samples in alpacas is similar to cats (166 ng/mL), but the Cmax from the CV samples failed to reach that reported in dogs (140 ng/mL) and people (123 ng/mL). Conclusions: Plasma concentrations of MRZ were significantly different between sampling sites, resulting in different interpretations for potential use in alpacas. Clinical Relevance: Additional information is needed before using oral MRZ in alpacas, including studies of different doses, formulations, or routes of administration.
DOI: 10.2460/ajvr.25.07.0252
Authors: Emilee K. Lacey, Katherine E. Wilson, Jennifer L. Davis
Language: English
Subfield: Small Animals
Field: Veterinary
Open Access status: diamond
OpenAlex ID: W4415509662
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