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Medulloblastoma Presenting With Bilateral Internuclear Ophthalmoplegia of Abduction: A Case Report

Year: 2025

Type: article

Abstract: Medulloblastoma is the most common paediatric high-grade central nervous system tumour. To our knowledge, this is the first case of medulloblastoma presenting with bilateral internuclear ophthalmoplegia (INO) of abduction. We describe a rare case of a 14-year-old girl presenting with bilateral abduction deficits and optic disc swelling. Neuroimaging revealed a midline posterior fossa tumour consistent with medulloblastoma compressing the dorsal pons and 4th ventricle. Following surgical resection and adjuvant therapy, ocular motility normalized. This case report highlights the features of a rare horizontal gaze palsy; bilateral posterior INO of abduction, resulting from the mass effect of a large medulloblastoma. Such a rare presentation requires a high index of suspicion and familiarity with neuroanatomy and neuro-ophthalmic examination in order to ensure correct diagnosis, prompt investigation, and treatment of the cause.

Source: Cureus

DOI: 10.7759/cureus.95315

Authors: Andrew Palmier, Sarah Grech

Institution: Mater Dei Hospital

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415512680