Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To assess the frequency of PDL-1 positivity in triple-negative breast carcinoma (TNBC) and correlate it with the clinicopathological parameters. Study Design and Setting: Cross-sectional study conducted at Histopathology Department of Rehman Medical Institute, Peshawar. Methodology: The study period was from September 2023 to October 2024. Biopsy specimen of 41 female patients diagnosed with TNBC were received in the Histopathology department. Specimens underwent eosin/hematoxylin staining and immunohistochemistry analysis. Demographic and histopathological parameters were recorded and analyzed using SPSS version 23. Results: Mean age was 54.58(6.14) years, and the most common type of TNBC was invasive breast carcinoma of no special type in 23(56.1%). Out of 41 specimens, we observed that stage N2 and stage T3 were the most prevalent as observed in 18(43.9%) and 19(46.3%) specimens respectively. Frequency of PDL-1 positivity was observed in 16(39.02%) with a trend towards higher PDL-1 positivity observed in invasive ductal carcinoma of no special type and tumors exhibiting size of >20mm. Lymphovascular invasion was seen in 17 (41.46%) out of which 09 (56.3%) were PDL-1 positive. Tumor-infiltrating lymphocytes of the moderate category were significantly associated with PDL-1 positivity with a p-value of 0.024. Conclusion: PDL-1 expression is observed in a substantial number (39.02%) of TNBC patients. Our research concludes an important association between PDL-1 expression and tumor-infiltrating lymphocytes in TNBC which enlightens new avenues for immunotherapy. This association may have profound implications in the future for prompt diagnosis and targeted treatment.
Author: Maria Khan
Institution: Rehman Medical Institute
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4415513524