Year: 2025
Type: article
Study design: Case Report
Abstract: Congenital leukemia is a very rare but severe disease diagnosed within the first 28 days of life. Common symptoms include hepatosplenomegaly, leukemia cutis, pallor, petechiae, leukocytosis, and thrombocytopenia. This report presents three full-term newborns diagnosed with congenital leukemia. Examination of all three patients showed hepatosplenomegaly, petechiae, and thrombocytopenia, although the symptoms appeared at a different time in each case. Due to the non-specific nature of early symptoms, cytological analysis, cytogenetic testing, and immunophenotyping are essential for establishing a definitive diagnosis. Congenital leukemia is a rare condition that requires early diagnosis, personalized treatment, and ongoing research. Despite progress in neonatal care, the prognosis of this condition remains poor, highlighting the importance of developing better diagnostic tools and therapeutic strategies.
Source: Cureus
DOI: 10.7759/cureus.95318
Authors: Zuzanna Karczmarzyk, Magdalena Szuba, Joanna Krupa, Natalia Czaplińska, Bożena Kociszewska-Najman
Institution: Medical University of Warsaw
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415513864