Work

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Year: 2025

Type: article

Abstract: ABSTRACT Formate bioconversion plays a crucial role in achieving renewable resource utilization and green and sustainable development, as it helps convert formate to biofuels and biochemicals. However, to tap the full potential of formate bioconversion, it is important to identify the most appropriate microbial hosts, design the most promising formate assimilation pathways, and develop the most efficient formate assimilation cell factories. Here, we summarize the formatotrophic microorganisms capable of assimilating formate into building blocks of cell growth and analyze the characteristics of formate assimilation pathways for transmitting formate into central carbon metabolism. Furthermore, we discuss microbial engineering strategies to improve the efficiency of formate utilization for producing high‐value bioproducts. Finally, we highlight the key challenges of formate bioconversion and their possible solutions to advance the formate bioeconomy and biomanufacturing.

Source: Carbon Energy

DOI: 10.1002/cey2.70064

Authors: Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen

Institution: Jiangnan University

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Affordable and clean energy, Responsible consumption and production, Climate action

Open Access status: gold

Estimated APC paid: $3,200