The Italian network for severe malaria treatment (NOMAL): epidemiology, clinical presentation, management and outcomes in a non-endemic setting
Year: 2025
Type: article
Study design: Observational Study
Abstract: Severe malaria is a medical emergency that may result in death [1]. Prompt diagnosis and adequate treatment are essential for the successful clinical management and for reducing the risk of death [2]. Most of the current knowledge on severe malaria is based on observations and results of studies carried out in malaria endemic countries. However, such evidence may not be completely relevant to non-endemic settings [3]. Indeed, severe malaria in endemic countries with stable transmission occurs mainly in children under 5 years of age and in pregnant women while in older children and adults, although they can still suffer of uncomplicated malaria, severe disease is extremely rare thanks to the partial immunity they've acquired over years of exposure to infective bites. Such semi-immune status prevents the evolution of uncomplicated malaria towards severe disease.
Authors: Tommaso Ascoli Bartoli, Angela Corpolongo, Alessandra D'Abramo, Andrea Angheben, Giulia Bertoli, Katleen de Gaetano Donati, Roberto Cauda, Spinello Antinori, Luciano Attard, Giordano Madeddu, Lina Rachele Tomasoni, Carlo Pallotto, Antonella Vulcano, Gaetano Maffongelli, Lorenzo Zammarchi, Gabriella d'Ettorre, Assunta Navarra, Enrico Girardi, Umberto D'Alessandro, Emanuele Nicastri
Institutions: Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Ospedale Sacro Cuore Don Calabria, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, University of Milan, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, University of Sassari, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Brescia, University of Perugia, University of Florence, Sapienza University of Rome, London School of Hygiene & Tropical Medicine, MRC Unit the Gambia, Medical Research Council
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,710
Funder: Ministero della Salute
OpenAlex ID: W4415517187