Control of hepatic gluconeogenesis in mice fed a high protein diet: a transcriptional shift from CREB to FoxO1
Year: 2025
Type: article
Abstract: The regulation of hepatic glucose production under a high-protein (HP) diet remains unclear. We show that gluconeogenesis in HP-fed mice is initially driven by CREB but shifts to FoxO1 dependence over time. Notably, FoxO1 is essential for maintaining gluconeogenesis and glycemia in HP-adapted animals. We also reveal a key role for corticosterone in preserving gluconeogenic capacity and fasting glycemia. These findings provide insights into hepatic metabolic adaptation and into molecular mechanisms governing glycemic homeostasis.
Authors: João Batista Camargo Neto, Henrique J. Novaes Morgan, Matheus Leonardo Moro, Ana Paula Assis, Leticia Cirelli Ruiz, Aline Zanatta Schavinski, Natalia E. S. Lautherbach, Luiz Carlos Navegantes, Isis C. Kettelhut
Institution: Universidade de São Paulo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4415522843