Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice
Year: 2025
Type: article
Abstract: Global loss of selenocysteine lyase controls the glutathione system in the heart, impacting glutathione peroxidase protein levels and activity, and glutathione levels in a mouse model of obesity. Loss of selenocysteine lyase and selenomethionine deficiency impacts cardiomyocyte function and selenoproteins in a sexually dimorphic nature, with females being affected more than males when mice are on a high-fat diet.
Institution: University of Hawaiʻi at Mānoa
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities, Hawai'i Community Foundation
Awards: G2334344892, G2891986309, G2912100404, Investigating sex-specific metabolic effects of disrupted selenocysteine lyase and selenocysteine tRNA in Agrp hypothalamic neurons, G4547751092, G4769913333, G568052834, Mechanism of Selenoprotein Synthesis, G8410070784, Ola HAWAII, University of Hawaii Cancer Center CCSG, MARC at University of Hawaii at Manoa, Training in Cardiovascular Research at the University of Hawaii
OpenAlex ID: W4415523905