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Transplacental oxygen transfer during physiological-based cord clamping in preterm lambs

Year: 2025

Type: article

Abstract: This study investigated transplacental oxygen transfer during physiological-based cord clamping in preterm lambs. During physiological-based cord clamping, ventilating newborn lambs reduced oxygen uptake across the placenta and that ventilation with high oxygen (1.0 [Formula: see text]) reversed the oxygen gradient, resulting in newborn to mother oxygen transfer. Our findings indicate that the mother can act as an "oxygen sink" that protects the newborn from excess oxygen during physiological-based cord clamping.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00641.2025

Authors: Ebony R. Cannata, Janneke Dekker, Stuart B. Hooper, Alison M. Thiel, Cailin Diedericks, Paige J. Riddington, Valerie A. Zahra, Arjan B. te Pas, Graeme R. Polglase, Douglas A. Blank, Kelly J. Crossley

Institutions: Hudson Institute of Medical Research, Monash University, Leiden University, Leiden University Medical Center, Willem-Alexander Kinderziekenhuis, Monash Medical Centre, Monash Health

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Jack Brockhoff Foundation, Department of Health and Aged Care, Australian Government, National Health and Medical Research Council

Awards: G2087783563, Improving Neonatal Resuscitation, G3890882244, G4473930647, G743525432

OpenAlex ID: W4415524895

FWCI: 2.354

Cites: 37

Cited by: 4

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