Work

Acquired hemophilia A in an elderly female with bullous pemphigoid: Case report

Year: 2025

Type: article

Abstract: RATIONALE: Acquired hemophilia A (AHA) is a rare but life-threatening bleeding disorder, necessitating enhanced recognition in patients with concomitant autoimmune diseases. PATIENT CONCERNS: A 91-year-old female with bullous pemphigoid presented with spontaneous subcutaneous bleeding and prolonged activated partial thromboplastin time. DIAGNOSES: Laboratory investigations revealed a decrease in factor VIII activity to 6.4%, confirming the diagnosis of bullous pemphigoid-associated AHA. INTERVENTIONS: The patient was subjected to monotherapy with glucocorticoids and supportive hemostatic measures. OUTCOMES: Coagulation parameters normalized within 1 month, and no severe complications occurred. LESSONS: This case highlights the importance of considering AHA in elderly patients with autoimmune diseases who present with unexplained bleeding. An individualized treatment strategy may improve clinical outcomes.

Source: Medicine

DOI: 10.1097/md.0000000000045325

Authors: Zhongmei Liu, Junzhu Xu

Institution: Third People's Hospital of Hangzhou

Language: English

Topic: Hemophilia Treatment and Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950