Pharmacokinetic, toxicological, and antidiabetic evaluation of a novel polyherbal formulation
Year: 2025
Type: article
Abstract: OBJECTIVES: . METHODS: NPF was prepared and subjected to preliminary phytochemical screening and FTIR to characterize its bioactive compounds and functional groups. To assess the safety, oral toxicity studies were carried out in Wistar rats. The antidiabetic efficacy was evaluated using the OGTT. Additionally, computational ADME analysis was carried out for the major active molecules - arjunolic acid, embelin, and asiaticoside - to evaluate the pharmacokinetic properties and drug-likeness. RESULTS: Presence of various secondary metabolites such as alkaloids, flavonoids, phenolic compounds, saponins, terpenoids, cardiac glycosides, and carbohydrates were confirmed by the phytochemical screening. Key prominent functional groups such as hydroxyl, amine, carbonyl, and alkyne stretching vibrations were detected upon FTIR analysis. Toxicity evaluations indicated no adverse effects, confirming the safety of NPF. Among diabetic rats, groups treated with 200 mg/kg body weight of NPF indicated a significant improvement in glucose tolerance as demonstrated by the OGTT results. ADME profiling showed favorable drug-likeness properties for arjunolic acid and embelin compared to asiaticoside. CONCLUSIONS: NPF exhibited significant antidiabetic potential and demonstrated safety in animal models.
Institution: Indian Institute of Science Bangalore
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,712
Funder: University Grants Commission
Award: G375168980
OpenAlex ID: W4415534515