Work

Integrated proteomic analysis identifies TYMS-dependent AMPK-mTOR signaling in pancreatic neuroendocrine tumors

Year: 2025

Type: article

Abstract: null transgenic mouse model. In addition, TYMS expression positively correlates with mTOR-associated genes in patients with PanNET. TYMS levels also impact the efficacy of everolimus, an FDA-approved mTOR inhibitor for patients with PanNET, underscoring the clinical significance of our findings. In summary, our study uncovers a new role of TYMS linking nucleotide metabolism to growth signaling pathways via the regulation of the AMPK-mTOR axis.

Source: iScience

DOI: 10.1016/j.isci.2025.113833