Work

Multi-cellular phenotypic dynamics during the progression of an immunocompetent breast cancer model

Year: 2025

Type: article

Abstract: + cytotoxic T cells, as well as C1q macrophages, increase in parallel with tumor progression. These findings establish the single-cell types and phenotypes in a progressing breast tumor, and reveal when these cellular players enter and leave the TME.

Source: iScience

DOI: 10.1016/j.isci.2025.113808

Authors: Louise Gsell, Spencer S. Watson, Iva Sutevski, Matteo Massara, Klara Soukup, Alper Eroglu, Jeff E. Mold, Antony Cougnoux, Johanna A. Joyce, Jean Hausser

Institutions: Science for Life Laboratory, Karolinska Institutet, Ludwig Cancer Research, University of Lausanne

Language: English

Topic: Single-cell and spatial transcriptomics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Breast Cancer Research Foundation, Ludwig Institute for Cancer Research, Cancer Research UK, European Commission, École Polytechnique Fédérale de Lausanne, Brain Tumour Charity, Cancerfonden, Karolinska Institutet, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Université de Lausanne, Science for Life Laboratory, Horizon 2020 Framework Programme

Awards: International Cancer Research Fellowships - 2, G235696346, G5034017624

OpenAlex ID: W4415534898

FWCI: 0.783

Cites: 112

Cited by: 3

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