Work

Congenital uterine anomalies and congenital heart disease: An underappreciated association?

Year: 2025

Type: article

Abstract: Background: Congenital uterine anomalies (CUAs), also known as Müllerian duct anomalies, can have an impact on gynecological care, pre-pregnancy counseling, and obstetrical outcomes. Patients with congenital heart disease (CHD), particularly of higher complexity, often have extracardiac malformations. The relationship between CUAs and CHD is not well-described in the currently available literature. Methods: A single center retrospective cohort study was performed of all patients born female with ICD-10 codes corresponding to congenital heart disease and a completed pelvic MRI or ultrasound. CT imaging was not included given the known shortcomings of CUA detection and classification with CT. CHD diagnoses were confirmed with echocardiography and were classified into “simple”, “moderate”, or “complex” per the 2018 ACHD guidelines. CUAs were categorized based on the 2021 American Society of Reproductive Medicine Guidelines for classification of Müllerian anomalies. Results: 197 patients met inclusion criteria. 33 (16.7%) were found to have a CUA. 17 (20%) patients with moderate or complex CHD had a CUA. Notable associations include VACTERL and partial anomalous pulmonary venous return. More complex CHD was associated with more complex CUA. Conclusions: Within the limitations of a single center retrospective study, our data suggests there is an underappreciated association between CUA and CHD that requires further prospective multicenter study to assess prevalence data. Our data suggests there may be a role for screening for patients with CHD for CUA, particularly those with moderate or complex CHD who are considering pregnancy or gynecologic intervention.

Source: International Journal of Cardiology Congenital Heart Disease

DOI: 10.1016/j.ijcchd.2025.100634

Authors: Harrison J. VanDolah, Kathy Mostajeran, Luis Goncalves, Wayne J. Franklin, Melissa Parks, Tabitha G. Moe

Institutions: University of Arizona College of Medicine- Phoenix, Phoenix Children's Hospital

Language: English

Topic: Gynecological conditions and treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,120