Regioselective Synthesis of 3‐Benzoyl‐4‐Phenyl‐4 H ,5 H ‐Thiopyrano[2,3‐ b ]chromen‐5‐One Derivatives through One‐Pot Domino Reaction Using Aromatic Aldehyde, β‐Enaminone, and 4‐Hydroxy‐2 H ‐Chromene‐2‐Thione
Year: 2025
Type: article
Abstract: A green, efficient, and regioselective one‐pot three‐component synthesis of 3‐benzoyl‐4‐phenyl‐4 H ,5 H ‐thiopyrano [2,3‐ b ]chromen‐5‐one derivatives has been developed. This protocol utilizes 4‐hydroxy‐2 H ‐chromene‐2‐thione, aromatic aldehydes, and β ‐enaminones, mediated by triphenylphosphine and N‐ bromosuccinimide. Notably, this protocol involves a Michael‐type addition followed by intramolecular cyclization. This methodology offers excellent product yields under mild reaction conditions, making it a valuable addition to synthetic protocols.
Institution: Indian Institute of Technology Guwahati
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funders: Department of Biotechnology, Ministry of Science and Technology, India, Department of Science and Technology, Ministry of Science and Technology, India, Ministry of Education, India, Indian Institute of Technology Guwahati, Directorate for Biological Sciences, North East Centre for Biological Sciences and Healthcare Engineering, Indian Institute of Technology Guwahati
OpenAlex ID: W4415535549