Work

Pyrrolo[2,1‐ f ][1,2,4]triazin‐4‐amine: Synthesis, C 7‐Functionalization, and NH 2 ‐Derivatization via Buchwald–Hartwig‐Type Coupling

Year: 2025

Type: article

Abstract: An optimized gram‐scale synthetic route to pyrrolo[2,1‐ f ][1,2,4]triazin‐4‐amine is reported, affording an overall yield of 85%. Furthermore, regioselective C 7‐functionalization is achieved via both organometallic and direct strategies, whereas NH 2 ‐derivatization proceeds through Buchwald–Hartwig‐type coupling, providing derivatives in isolated yields ranging from 8% to >99%. These advancements enhance synthetic accessibility and facilitate efficient structural diversification of this significant N ‐heterocycle.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500512

Authors: Vinícius Rodrigues Durães Pereira, Geovana Fontes Vargas, Taniris Cafiero Braga, Juliana Alves dos Santos, Giuliano Cesar Clososki, Jaime Alberto Rabi Nallar, Vagner Dantas Pinho, Giovanni Wilson Amarante

Institutions: Universidade Federal de Juiz de Fora, Universidade de São Paulo

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Awards: G1499616537, G2989526193, G3690646728, G3837754718, G3896905694, G4742337282, Exploring the medicinal chemical space of aromatics with highly selective synthetic tools, NOVAS METODOLOGIAS SINTÉTICAS PARA AS REAÇÕES CATALÍTICAS E ASSIMÉTRICAS DE PASSERINI E UGI: UMA ABORDAGEM EXPERIMENTAL E COMPUTACIONAL

OpenAlex ID: W4415535590

FWCI: 0.29

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Cited by: 1

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