Efficacy of Ibuprofen vs Acetaminophen for Pain Relief in Pediatric Dental Extractions: A Systematic Review
Year: 2025
Type: review
Abstract: These differing mechanisms of action raise important questions about the relative efficacy of each drug in treating postoperative dental pain, particularly where inflammation is a key factor.Previous research has suggested that ibuprofen may offer superior pain relief compared to acetaminophen in cases involving inflammation, such as dental extractions.7 In contrast, one study indicated that both drugs provide comparable pain relief when dosed appropriately, with acetaminophen offering a similar level of efficacy to ibuprofen.8 This variability in results underscores the IntroductIon "Some pains are physical, and some pains are mental, but the one that's both is dental."Ogden NashEffective management of postoperative pain in pediatric dental procedures, such as extractions, is essential for ensuring the comfort and well-being of young patients.Untreated pain can have immediate negative consequences, such as distress and reduced quality of life, as well as long-term effects such as fear and anxiety toward future dental treatments. 1 Postoperative pain is typically caused by tissue damage, inflammation, and nerve irritation, and if inadequately managed, can contribute to the development of chronic pain. 2 As a result, appropriate pain management is crucial for facilitating recovery and improving patient care outcomes.3,4 Given the unique challenges in treating pediatric patients, selecting appropriate analgesics is crucial to ensuring a positive treatment outcome.Ibuprofen and acetaminophen are commonly prescribed analgesics for pediatric patients following dental procedures.Ibuprofen is a type of nonsteroidal anti-inflammatory medication (NSAID) that helps reduce pain and swelling.It functions by blocking cyclooxygenase (COX) enzymes, which are essential in the body's inflammation process.By lowering prostaglandin levels, ibuprofen effectively minimizes both inflammation and discomfort.5 In contrast, acetaminophen primarily acts within the central nervous system.It works by blocking prostaglandin production in the brain, helping to reduce pain and fever, providing analgesic and antipyretic benefits without significant anti-inflammatory action.6
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415536032