Work

The antimicrobial potential of marine fungal derived natural and semisynthetic butyrolactones analogues against MRSA

Year: 2025

Type: article

Abstract: In our search for new antimicrobial agents from nature, the initial antimicrobial effect of the marine-derived fungus Aspergillus terreus strain 15F6 against Staphylococcus aureus and MRSA demonstrated promising effect. Large scale fermentation and bio-guided isolation led to the isolation of two natural butyrolactones ( 1 and 2 ). To study the structure activity relationship, we have prepared a few semisynthetic butyrolactone analogues with different substituents. Surprisingly, the semisynthetic analogue 1a demonstrated promising antimicrobial effect against MRSA but not S. aureus with MIC below 3 µM. Using in silico studies to unlock the potential mechanisms behind these observations, we have found that the new semisynthetic butyrolactone analogues successfully bind to the Mur-B binding site.

Source: Journal of Molecular Structure

DOI: 10.1016/j.molstruc.2025.144511

Authors: Hani A. Alhadrami, Bathini Thissera, Marija Nekrasova, Albaraa H. Alhadrami, Mostafa E. Rateb, Asmaa M. AboulMagd

Institutions: University of the West of Scotland, Nahda University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360