Work

Tetrazine- trans -cyclooctene ligated lanthanide conjugates for biomedical imaging

Year: 2025

Type: article

Abstract: Tetrazine-functionalised lanthanide chelates and their catalyst-free ‘click’ reactions with a trans -cyclooctene-rhodamine fluorophore are reported. These probes were delivered across the blood–brain barrier using focused ultrasound and microbubbles.

Source: Inorganic Chemistry Frontiers

DOI: 10.1039/d5qi01745a

Authors: Hongxuan Chen, William Lim Kee Chang, Grace T. McMullon, Yichao Yu, Benjamin P. Woolley, Gráinne Geoghegan, Ceren Yalcin, Sophie V. Morse, Mark F. Lythgoe, James J. Choi, Nicholas J. Long

Institutions: Imperial College London, University College London, UK Dementia Research Institute

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: Cancer Research UK, Imperial College London, Rosetrees Trust, Brain Tumour Charity, John Black Charitable Foundation, Engineering and Physical Sciences Research Council, EPSRC Centre for Doctoral Training in Medical Imaging

Awards: G2478362894, G3509749838, G3789196742, G4064828671, EPSRC Centre for Doctoral Training in Smart Medical Imaging at King's College London and Imperial College London, G7812459551, Translational nanoconstructs for targeted tissue accumulation and guided surgery in cancer, G8268203974

OpenAlex ID: W4415544446

FWCI: 0.212

Cites: 72

Cited by: 1

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