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Uremic serum exposure leads to differential phenotypic switch in porcine arterial and venous smooth muscle cells

Year: 2025

Type: article

Abstract: This study was the first one to directly explore the differential response of arterial VSMCs and venous VSMCs to uremic serum exposure side by side. Both similarities and differences were detected in this in vitro study, which provides insight into the clinical manifestations we observed in patients with ESKD. Furthermore, these results may also be valuable information for uremia-specific therapies for both vascular access dysfunction and CVD/PAD in patients with ESKD.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00217.2025

Authors: Huanjuan Su, Unimunkh Uriyanghai, Christine Wai, Eyla C. Arteaga, Haibao Wan, Klaus-Peter Adam, Vinay A. Sudarsanam, Samuel O’Brien Haddad, Anthony Yang, Lianxia Li, Edward M. Bahnson, John S. Poulton, Prabir Roy-Chaudhury, Gang Xi

Institutions: University of North Carolina at Chapel Hill, W. G. (Bill) Hefner VA Medical Center

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases

Awards: G2560521705, Pathobiology of ANCA Glomerulonephritis: Targeting Adaptive and Innate Immune Processes for Precision Therapies, G4951618211, Modulation of VSMC phenotype through the Insulin Receptor Substrate-1/Kruppel-like factor-4 signal transduction pathway: a Novel Target for AVF Dysfunction

OpenAlex ID: W4415547159

FWCI: 1.816

Cites: 33

Cited by: 3

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