Decoding fibrosis in nonresolvable COVID-19: a role for myeloid-specific HIF1A deletion
Year: 2025
Type: article
Abstract: Postviral-induced lung fibrosis represents a severe and potentially fatal outcome. This was most evident during the COVID-19 pandemic, where a subset of individuals presented with fulminant lung fibrosis requiring lung transplantation. The mechanisms that promote this exacerbated lung injury are not fully known. Herein, we demonstrate that mice lacking myeloid hypoxia-inducible factor 1A (HIF1A) develop an exacerbated lung injury response to bleomycin that was consistent with reduced macrophage HIF1A expression in nonresolvable (NR)-COVID-19, characterized by extensive lung fibrosis.
Authors: Kemly Philip, Hannah P. Thompson, Scott D. Collum, Isabella Lefebvre, Bindu Akkanti, Bihong Zhao, Rahat Hussain, Manish Patel, Michael R. Blackburn, Tingting W. Mills, Harry Karmouty-Quintana
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Regulatory role of APA in pulmonary fibrosis during aging, 3'UTR Shortening in Pulmonary Vascular Disease, CFlm25 mediated alternative polyadenylation regulates fibrosis in systemic sclerosis, Macrophage NUDT21-mediated alternative polyadenylation in lung injury, Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary Fibrosis, Ribosome Dysfunction in Lung Fibrosis, Sine Oculis Homeobox Homolog 1 and clusterin in Pulmonary Hypertension associated with Systemic Sclerosis
OpenAlex ID: W4415547362