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Liver androgen receptor knockout attenuates high-fructose diet-induced glucose dysregulation in female mice

Year: 2025

Type: article

Abstract: To our knowledge, this study is the first to demonstrate that liver-specific androgen receptor (AR) deletion in female mice provides selective protection against fructose-induced insulin resistance. Although hepatic AR loss improves insulin sensitivity, it does not fully preserve insulin secretion or gluconeogenic control, revealing a sex-specific, dichotomous role of hepatic AR in metabolic regulation. These findings highlight hepatic AR as a potential therapeutic target for diet- and androgen-related metabolic dysfunction in females.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00254.2025