Work

Association of Sarcopenic Obesity with Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms: A Nationwide Cross-sectional Study

Year: 2025

Type: article

Abstract: Background and objective: This study explores the associations of sarcopenia, obesity, and their coexistence (sarcopenic obesity) with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Methods: ), and sarcopenic obesity. LUTS/BPH was assessed according to each patient's medical history. Logistic regression was used to evaluate the association of obesity, sarcopenia, and sarcopenic obesity with BPH/LUTS. Interaction effects were further assessed to investigate the combined impact of sarcopenia and obesity. Key findings and limitations: = 0.9). Sensitivity analyses confirmed these findings. The interaction between sarcopenia and obesity was significant, with 40% (95% CI 13-56%) of the risk attributed to their combined effect. Conclusions and clinical implications: Sarcopenic obesity was independently associated with higher risk of BPH/LUTS among older men in our cohort. Our study highlights the synergistic interaction between sarcopenia and obesity, and suggests a need for comprehensive management of both conditions to reduce the risk of BPH/LUTS. Patient summary: We looked at associations between a condition called sarcopenic obesity (obesity and a loss of muscle mass) and benign enlargement of the prostate gland causing urinary problems (called BPH/LUTS for short). We found that sarcopenic obesity is associated with a higher risk of BPH/LUTS in older men.

Source: European Urology Open Science

DOI: 10.1016/j.euros.2025.10.005

Authors: Zhonghan Zhou, Gongyue Liu, Junjie Ji, Yixi Liu, Limin Liao

Institutions: Capital Medical University, China Rehabilitation Research Center

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800