Zn and Al vapour-phase metalation of polyamide-6 via ALD: structural, functional, and biomedical insights
Year: 2025
Type: article
Abstract: This study reports the effect of diethylzinc (DEZ) and trimethylaluminium (TMA) functionalization on polyamide-6 (PA6) films using the vapour-phase metalation (VPM) process within an atomic layer deposition (ALD) chamber. The resulting zinc- and aluminium-functionalized films are referred to henceforth as PA6-Zn and PA6-Al, respectively. Biocompatibility was preliminarily assessed via C2C12 cytotoxicity testing. Reaction mechanisms were examined using density functional theory, electrostatic potential maps, Mulliken charge distribution, and X-ray photoelectron spectroscopy, revealing interactions between metal precursors and PA6 amide groups. DFT confirmed α-PA6 as the dominant structure and identified reactive sites influencing functionalization pathways. Structural and morphological changes were analysed via environmental scanning electron microscopy and X-ray diffraction. ESEM showed Zn-functionalized PA6 forming strand-like structures, while Al-functionalized PA6 developed pore-like cavities. XRD indicated increased crystallinity upon metalation, with the α/γ crystallite size ratio following the trend: PA6-Al > PA6-Zn > PA6. Spectroscopic analysis using infrared and Raman microscopy, along with UV–visible spectroscopy, highlighted modifications in chemical bonding and polymorphism, aligning with DFT predictions. Al functionalization had a stronger influence on PA6’s spectroscopic and some mechanical properties, whereas Zn functionalization notably enhanced failure strain. Barrier and mechanical properties were evaluated, showing that Zn-functionalized PA6 exhibited superior oxygen permeability, while both metal-modified films improved water vapour transmission rates compared to bare PA6. Cytotoxicity testing revealed enhanced C2C12 cell proliferation in the order PA6-Al > PA6-Zn > PA6, suggesting VPM-modified PA6 as a promising material for biomedical applications. Graphical Abstract
Source: Journal of Materials Science
Institutions: Merseburg University of Applied Sciences, Universidad SEK, Queen's University Belfast, University of Strathclyde, University of Ulster, Charité - Universitätsmedizin Berlin, University of Chile, Centro Científico Tecnológico de Valparaíso, Universidad Técnica Federico Santa María, Finis Terrae University, Max Planck Institute of Microstructure Physics, Hebrew University of Jerusalem
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,590
Awards: EVALUATION OF A MICROENGINEERING PLATFORM FOR THE DEVELOPMENT OF PERIPHERAL NERVE SUBSTITUTES., G141955430, G179677019, G1879083242, SIN INFORMACION, G2905376563, G4108186236, G4517854216, HYBRID LAYERED WIDE-BAND GAP SEMICONDUCTORS AS BUILDING BLOCKS FOR DESIGNING SUNLIGHT-DRIVEN EFFICIENT PHOTOCATALYTIC SYSTEMS, A multi-function XPS-UPS system with load-locked advanced sample preparation stages, G6321809664, G6686230471, G7367291098, G7731820719, G7984228675, G8799413597, APOYO BASAL 2023 CCTVAL
OpenAlex ID: W4415547762