Noninvasive elastography-based assessment of liver fibrosis in primary biliary cholangitis
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION AND OBJECTIVES: Transient elastography (TE) has been widely used in clinical practice, but noninvasive prediction models based on TE for the assessment of liver fibrosis in primary biliary cholangitis (PBC) has not been reported before. The aim of this study is to develop the simple, accurate and noninvasive prediction models for the histologic staging of PBC based on TE. PATIENTS AND METHODS: Serologic testing, liver stiffness measurement (LSM), and histological assessment of 144 patients with PBC were collected retrospectively. In model group consisted of 96 patients, LSM and alkaline phosphatase (ALP) were identified as two independent predictors of PBC histological stage, which were used to establish two noninvasive models, Model A and Model B, to predict significant fibrosis (Ludwig stage ≥ 2) and advanced fibrosis (Ludwig stage ≥ 3), respectively. The performance of noninvasive models was then validated in the validation group (48 patients). RESULTS: The area under the ROC curve (AUROC) of Model A was 0.870 (95 % CI, 0.802-0.939) in the model group and 0.914 (95 % CI, 0.803-1.000) in the validation group. The AUROC of Model B was 0.948 (95 % CI, 0.888-0.998) in the model group and 0.906 (95 % CI, 0.824-0.987) in validation group. The above results were higher than the other five serologic markers. CONCLUSIONS: The Model A and Model B were the efficient noninvasive models with high accuracy in predicting the histological stages of PBC.
Source: Annals of Hepatology
Institutions: Capital Medical University, Beijing Ditan Hospital
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4415559659