Work

Features of Peripheral T Cell Remigration into the Thymus

Year: 2025

Type: article

Abstract: The thymus, the central organ of T lymphopoiesis, is traditionally thought to exclusively export T cells. However, a great deal of studies has shown that mature peripheral T cells can return to the thymus and remain there. It is acknowledged that both CD4+ and CD8+ activated T cells can remigrate into the healthy adult thymus and accumulate predominantly in the medulla. In contrast, naïve T cells can actively populate the thymus of neonates and aged animals, potentially supporting the medulla’s functioning. Still, the fate and functions of peripheral T cell remigrants are not fully understood as of today. This review presents experimental findings on peripheral T cell remigration, analyzes phenotypic and traffic features of remigrants, and considers possible effects of backmigration on thymus function.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms262110391

Authors: Anastasiia A. Kalinina, Ludmila M. Khromykh, Dmitry B. Kazansky

Institutions: Russian Cancer Research Center NN Blokhin, Ministry of Health of the Russian Federation

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499