C-reactive Protein as a Diagnostic Biomarker in Psychiatric Disorders: Current Evidence and Future Directions
Year: 2025
Type: article
Abstract: Schizophrenia: Individuals with schizophrenia often exhibit higher levels of CRP, suggesting an inflammatory component in the pathophysiology of the disorder.Research by Orsolini et al. 1 noted that elevated CRP levels in patients with schizophrenia correlated with symptom severity and treatment resistance.Studies examining first-episode psychosis also indicate that patients may have elevated CRP levels compared to healthy controls, highlighting inflammation's role early in disease onset (Garcia-Rizo et al., 2022). 2 • Mood disorders: In mood disorders such as major depressive disorder (MDD) and bipolar disorder, increased CRP levels have been linked to the severity and course of the illness.Zeng et al. 3 observed that patients with higher CRP levels were more likely to experience severe depressive symptoms and resistance to standard treatment, particularly in cases of treatment-resistant depression.Further research by Desoky et al. 4 found that CRP levels might help differentiate between unipolar and bipolar depression, with higher levels indicating more severe depressive symptoms.• Anxiety disorders: Studies investigating CRP in anxiety disorders, though less extensive, suggest that elevated CRP levels might indicate an increased vulnerability to anxiety.In a cohort study, elevated CRP was linked to a higher risk of developing
Source: Eastern Journal of Psychiatry
Author: Tirthankar Dasgupta
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4415565324