Clinical validation of AWGC-defined cachexia in gastric cancer patients: impact on body composition and quality of life
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background The Asian Working Group for Cachexia (AWGC) has released consensus criteria for diagnosing cachexia in Asians. Nevertheless, there is limited data regarding the application of these criteria in cancer patients. This study aimed to assess the changes in body composition and quality of life in gastric cancer (GC) patients with cachexia defined by the AWGC criteria. Methods Body composition parameters were analyzed using CT images at the level of the third lumbar vertebra. The European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 (EORTC QLQ-C30) was used to evaluate health-related quality of life (HRQoL). The diagnosis of cachexia was according to the AWGC criteria and Fearon’s criteria. Results A total of 431 patients with GC was included in this study. Among them, 160 patients (37.1%) were diagnosed with cachexia according to the AWGC criteria and 166 patients (38.5%) were diagnosed with cachexia based on the Fearon’s criteria. The agreement between the two criteria for diagnosing cachexia was moderate ( k = 0.477, p < 0.001). Patients with AWGC-cachexia had significantly lower skeletal muscle index (SMI), visceral fat index (VFI), and subcutaneous fat index (SFI) compared to those without ( p < 0.001). The prevalence of poor HRQoL was notably higher in patients with AWGC-defined cachexia (78.12% vs. 33.21%, p < 0.001). Furthermore, AWGC-defined cachexia was independently associated with poor HRQoL (OR = 5.92, 95% CI: 3.27–10.73; p < 0.001), while Fearon-defined cachexia did not show such an association (OR = 1.51, 95% CI: 0.86–2.65; p = 0.154). Conclusion Patients with AWGC-defined cachexia showed significant changes in body composition and was independently associated with poor HRQoL.
Source: Frontiers in Nutrition
Authors: Yan Huang, Xi Wu, Yan Ge, Chen Wang, Xin Ding, Junbo Zuo
Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415566155