Breaking barriers in the first-line Helicobacter pylori treatment: Chinese multicenter trial validates vonoprazan-based triple therapy
Year: 2025
Type: article
Abstract: presented compelling results from a multicenter randomized controlled trial in China, demonstrating the non-inferiority and potential superiority of vonoprazan (VPZ)-based triple therapy over the standard 14-day bismuth quadruple regimen. Both the 10-day and 14-day VPZ-amoxicillin-clarithromycin regimens achieved eradication rates exceeding 90% per protocol, with similar or fewer adverse events, suggesting improved patient tolerability. This study reinforces the potential of VPZ to overcome the limitations of proton pump inhibitor-based regimens, particularly in populations with CYP2C19 polymorphisms and increasing clarithromycin resistance. These findings also lend support to shortened treatment durations, which could enhance adherence and reduce antimicrobial exposure. These data highlight an important shift in the therapeutic landscape, positioning VPZ as a strong candidate for first-line empirical therapies. However, broader implementation requires careful consideration of local resistance patterns, drug accessibility, and pharmacoeconomic implications.
Authors: Vasily Isakov, Alexei Goncharov
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415566553