Work

Unusual presentation of synchronous double primary gallbladder and hepatic malignancies: A case report

Year: 2025

Type: article

Abstract: BACKGROUND: Synchronous double primary malignancies of the gallbladder and liver are exceedingly rare clinically and prone to misdiagnosis as metastatic lesions. Due to anatomic contiguity and overlapping imaging characteristics, distinguishing primary carcinomas from metastatic disease is challenging, often delaying curative-intent treatment. Current lack of consensus on management underscores the imperative to investigate their pathologic features and individualized strategies for improved prognostication. CASE SUMMARY: This study presents a rare case of synchronous double primary malignancies involving both gallbladder adenocarcinoma and hepatocellular carcinoma. Following a comprehensive analysis of the patient's diagnostic workup, therapeutic interventions, and 12-month follow-up outcome, the clinicopathological characteristics and prognostic determinants of such synchronous malignancies are described. These findings offer valuable guidance for clinicians in optimizing diagnostic strategies and treatment decision-making for complex presentations of multiple primary cancers. CONCLUSION: metastatic lesions and propose a multidisciplinary management framework.

Source: World Journal of Hepatology

DOI: 10.4254/wjh.v17.i10.110029

Authors: Kun Zhang, Hong-Liang Liu

Institutions: Affiliated Hospital of Qingdao University, Qingdao Women and Children's Hospital

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Sanofi, Teva Pharmaceutical Industries, Astellas Pharma