Work

Prognostic role of histone deacetylase 10 in colorectal cancer: Strengths and gaps

Year: 2025

Type: article

Abstract: Histone deacetylase 10 (HDAC10) is emerging as a critical modulator of tumor immunity, chemoresistance, and transcriptional plasticity in colorectal cancer. Its suppression has been linked to altered CD8+ T cell activity, increased p53 expression, and reduced programmed death ligand 1 levels, suggesting a potential role in immune evasion. However, mechanistic understanding of HDAC10’s selective function, especially in shaping the tumor microenvironment, remains limited. We advocate for targeted investigations using isoform-selective inhibitors, functional in vivo studies, and immune subset profiling to clarify HDAC10’s therapeutic relevance in colorectal cancer.

Source: World Journal of Gastroenterology

DOI: 10.3748/wjg.v31.i40.111951

Authors: Ali Afzal, Chatchai Muanprasat, Muhammad Babar Khawar

Institutions: University of Chinese Academy of Sciences, Yangzhou University, Ramathibodi Hospital, Ramathibodi Chakri Naruebodindra Hospital

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid