Work

Repurposing medications to prevent psychosis

Year: 2025

Type: review

Abstract: Individuals who experience schizophrenias often had premorbid signs. However, they rarely develop psychosis until adolescence or young adulthood, a period of brain remodeling. Current efforts to reduce risk for psychosis have shown only modest benefit. This paper reviews evidence on mechanisms that may underlie the development of psychosis. Based on that evidence, it identifies existing medications that target these mechanisms and may be repurposed to prevent progression to psychosis.

Source: npj Mental Health Research

DOI: 10.1038/s44184-025-00169-z

Authors: Bruce M. Cohen, Donna L. McPhie, Kai-Christian Sonntag, Claudia Lopes, Suzann M. Babb

Institutions: Harvard University, McLean Hospital

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,390