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Photoprotective Properties of Extracts Derived from Neoglaziovia variegata (Arruda) Mez Incorporated into Mesoporous TiO 2

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The development of safe and effective photoprotective agents has gained increasing interest in recent years, particularly through the incorporation of natural compounds into inorganic matrices. In this study, sunscreen formulations were developed by incorporating Neoglaziovia variegata (Arruda) Mez extracts into mesoporous TiO 2, using different solvent fractions: ethyl acetate, ethanol, chloroform, and hexane. Structural characterization confirmed the efficient incorporation of the extracts into the mesoporous channels of TiO 2, without compromising its crystallinity. Chemical analysis showed that the ethanolic and ethyl acetate extracts had the highest total phenolic content (1.550 ± 0.041 and 1.346 ± 0.004 mg GAE g –1, respectively) and the highest antioxidant activity (IC 50 values of 49.03 ± 1.24 and 59.34 ± 1.44 μg mL –1, respectively). These results directly correlated with higher Sun Protection Factor (SPF) values. The pure ethyl acetate and ethanol extracts showed the highest SPF values, reaching 26 and 10.5, respectively. Notably, the incorporation of the extracts into TiO 2 resulted in a marked increase in photoprotective efficacy. For example, the chloroform and hexane extracts, which had isolated SPF values of 3.9 and 1.1, reached values of 35 and 33, respectively, after incorporation, demonstrating a synergistic effect between the inorganic matrix and the plant’s bioactive compounds. Toxicological tests performed on blood agar and Artemia salina indicated that the presence of TiO 2 significantly reduced the toxicity of the pure extracts, demonstrating their biocompatibility. Spreadability tests revealed good coverage capacity for all formulations, favoring easy and uniform skin application. These results suggest that the developed hybrid systems represent a promising and safe alternative for the formulation of natural sunscreen products.

Source: ACS Omega

DOI: 10.1021/acsomega.5c06956

Authors: Francisco A. A. Miranda, Vaeudo V. Oliveira, Roosevelt D. S. Bezerra, Josy A. Osajima, Edson C. Silva-Filho

Institutions: Universidade Estadual do Maranhão, Universidade Estadual do Piauí, Instituto Federal do Piauí, Universidade Federal do Piauí

Language: English

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935