Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1‑dependent oxidative stress
Year: 2025
Type: article
Abstract: of cisplatin, increased ROS accumulation, aggravated DNA damage, and potentiated apoptotic cell death. Notably, ML171 attenuated ROS generation and apoptotic effects, confirming the occurrence of a NOX1-dependent mechanism. In conclusion, Hesperadin enhances the sensitivity of GC cells to cisplatin by inducing NOX1-mediated oxidative stress and promoting mitochondrial dysfunction-driven apoptosis, underscoring its potential as an effective combinatorial therapeutic strategy for GC treatment.
Source: Biomedical Reports
DOI: 10.3892/br.2025.2076
Authors: Wanjing Zhu, Qiyin Li, Zhenglei Ji, Di Wu, Jingya Chen, Yunli Zhao, Huazhang Wu
Institution: Bengbu Medical College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4415584913
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