Work

Pregnant women of advanced maternal age have higher central arterial stiffness than younger pregnant women throughout pregnancy and postpartum

Year: 2025

Type: article

Study design: Observational Study

Abstract: This study assessed the impact of advanced maternal age (AMA) on vascular and autonomic function across all three trimesters. Compared with younger pregnant women, women of AMA exhibited higher arterial stiffness and greater carotid intima-media thickness, and impaired autonomic regulation throughout pregnancy, despite no significant difference in endothelial function. These observed differences may represent early subclinical changes in AMA women, which may bring them closer to a physiological threshold where complications may occur.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00729.2025

Authors: Ruda Lee, Mark K. Santillan, Donna A. Santillan, Amy K. Stroud, Virginia R. Nuckols, Lyndsey E. DuBose, Seth W. Holwerda, Rachel E. Luehrs, Alexandria M. Betz, Debra Brandt, Gary L. Pierce, Anna E. Stanhewicz

Institution: University of Iowa

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia, G4897223407, Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers, Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics

OpenAlex ID: W4415590742

FWCI: 0.63

Cites: 58

Cited by: 1

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