Work

From Obscurity to Opportunity: LpxH Emerges as a Promising Antibiotic Target in the Battle against Gram-Negative Pathogens

Year: 2025

Type: review

Source: ACS Infectious Diseases

DOI: 10.1021/acsinfecdis.5c00625

Authors: Patrick A. Dome, C. Skyler Cochrane, Hannah J. Switzer, Hyejin Lee, Pyeonghwa Jeong, Jiyong Hong, Pei Zhou

Institution: Duke University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens, Biochemistry and Structure of Lipid A Enzymes, LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales

OpenAlex ID: W4415596301

FWCI: 0.384

Cites: 55

Cited by: 6

Related to: 10