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The Potential of Hypofractionated Radiotherapy: A Revolutionary Treatment for Anorectal Malignant Melanomas

Year: 2025

Type: article

Abstract: Mucosal melanomas generally arise from mucosal epithelium lining the respiratory, alimentary, and genitourinary tracts and usually carry worse prognosis than cutaneous melanomas. Anorectal melanomas account for 50% of gastrointestinal tract melanomas and 0.3 to 1% of all malignant melanomas. There are no specific treatment guidelines due to the scarcity of the disease, its unique biology, and challenges in management owing to the anatomic location. We report a case of anorectal malignant melanoma treated successfully with abdominoperineal resection followed by hypofractionated radiotherapy in a setting where financial toxicity limits treatment options. The patient presents complete response 2 years postdiagnosis, emphasizing that radiation therapy can be utilized for more than just palliation.

Source: Brazilian Journal of Oncology

DOI: 10.1055/s-0045-1812295

Authors: Vandana Thakur, Poorva Vias, Hardik Sharma, Pratibha Prashar, Aditya Jamwal, Anupam Thakur

Institutions: Dr. Rajendra Prasad Government Medical College, Post Graduate Institute of Medical Education and Research

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415599836