Work

Access to Bis(imidazopyridine)sulfanes by Employing Cysteine as a Greener Sulfur Source

Year: 2025

Type: article

Abstract: An efficient and environmentally friendly protocol has been developed for synthesizing bis(imidazopyridine)sulfanes, employing cysteine as sulfur source. This method demonstrates broad substrate scope, accommodating diverse electron-donating and electron-withdrawing functional groups on the imidazopyridine core. Furthermore, the protocol is successfully extended to other heterocycles: indole, azaindole, and benzo[ d ]imidazo[2,1 -b ]thiazole. Notably, this unique mechanistic approach obviates the need for transition metal catalysts, and additives, offering a significant advantage over existing synthetic methodologies

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01748

Authors: Pallavi Saha, Mohit Kumar, Deepak K. Sharma

Institutions: Indian Institute of Technology BHU, Banaras Hindu University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: Indian Council of Medical Research, Ministry of Education, India, Indian Institute of Technology (BHU) Varanasi, Science and Engineering Research Board