Work

Multicomponent Strategy for the Synthesis of 2,3‐Dihydro‐4 H ‐Imidazol‐4‐Ones under Catalyst‐ and Additive‐Free Conditions

Year: 2025

Type: article

Abstract: A catalyst‐ and additive‐free multicomponent reaction is developed for synthesizing substituted 2,3‐dihydro‐4 H ‐imidazol‐4‐ones from readily available benzoylformates, ketones, and ammonium salts. This protocol features dual nitrogen incorporation from ammonium salts and four CN bonds formation in one pot under optimized conditions. It exhibits broad substrate scope and good functionality tolerance, aligning with green chemistry principles.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500845

Authors: Feng Zhao, Zixuan Tan

Institution: Hunan University of Medicine

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Award: G7447749190