Work

Cannabinoids in immune system-related diseases: From bench to clinic

Year: 2025

Type: article

Abstract: ABSTRACT: As a psychoactive drug, marijuana is used for recreational purposes. Given its addictive nature and the serious damage it causes to both individual health and social stability, marijuana has been banned in most countries worldwide. In recent years, with the continuous improvement of basic research, researchers have discovered the role of cannabinoids, the primary active ingredient in marijuana, in multiple human systems. Research found that cannabinoids can regulate immune system function and have therapeutic potential in immune system-related diseases. However, the use of cannabinoids still poses certain hazards. For instance, cannabinoids can exert certain impacts on fetal nervous system development; cannabinoids use can lead to adverse reactions such as dizziness, nausea, and dry mouth. Moreover, there are still numerous contradictions in current research on the effects of cannabinoids, and the mechanisms by which cannabinoids exert protective effects in certain diseases remain unelucidated. In this review, we systematically discuss the endocannabinoid system and summarize the molecular and cellular bases of cannabinoid function in the immune system, and elucidate the effects of cannabinoids on immune system-related diseases.

Source: Chinese Medical Journal

DOI: 10.1097/cm9.0000000000003818