Work

Association of Carbohydrate Antigen 125 Levels and Right Ventricular Dysfunction in Patients With Chronic Obstructive Pulmonary Disease: A Cross‐Sectional Study

Year: 2025

Type: article

Abstract: Background and Aims Chronic obstructive pulmonary disease (COPD) patients with right ventricular (RV) dysfunction have poor prognoses, and early detection of RV dysfunction is beneficial. Therefore, we aimed to determine the association between CA125 levels and RV dysfunction in patients with COPD. Methods We enrolled 40 patients with stable COPD underwent echocardiography and the serum CA125 levels were measured. Results The mean CA125 level was higher in COPD patients with RV dysfunction (17.28 ± 27.35 U/mL) than without (10.94 ± 10.62 U/mL); however, it was not statistically significant ( p = 0.147). Additionally, tricuspid annular plane systolic excursion and pulmonary arterial pressure were not significantly different, while RV free wall strain (RVFWS) was decreased in the COPD patients with RV dysfunction when compared to the patients without RV dysfunction ( p < 0.001). Moreover, the CA125 level was remarkably correlated with RVFWS ( r = −0.497, p = 0.03) and FAC ( r = 0.51, p = 0.025) in patients with RV dysfunction. Conclusion We found that the CA125 level may not be beneficial in detecting RV dysfunction in stable COPD patients without exacerbation or hospitalization. However, further examinations with larger sample sizes are necessary to confirm our findings.

Source: Health Science Reports

DOI: 10.1002/hsr2.71410

Authors: Leila Bigdelu, Amir Mohammad Hashem Asnaashari, Samira Seifi, Reza Basiri, Vafa Baradaran Rahimi

Institution: Mashhad University of Medical Sciences

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,280