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Benzilmonoximethiocarbohydrazide Schiff bases as multifunctional antimalarial and antioxidant scaffolds: synthesis, biological evaluation, and mechanistic insights

Year: 2025

Type: article

Abstract: = 21.6 μM) with reduced toxicity toward HEK-293 cells. Mechanistic assays suggested apoptosis induction, suppression of pro-inflammatory mediators, and enhancement of antioxidant defense pathways. Complementary computational studies supported the experimental findings, showing favorable electronic properties, stable binding to malarial protein targets, and drug-like pharmacokinetic predictions. Collectively, these results establish HBMT Schiff bases, particularly HBMT-3M4HB, as promising multifunctional scaffolds with combined antimalarial, antioxidant, and selective cytotoxic activities, offering potential for further preclinical development.

Source: RSC Advances

DOI: 10.1039/d5ra06425b